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Ectopic CD137 expression facilitates the escape of hodgkin and reed-sternberg cells from immunosurveillance

OncoImmunology (2013) 2(4)
DOI: 10.4161/onci.23441
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Abstract

CD137 is ectopically expressed on Hodgkin and Reed-Sternberg (HRS) cells, causing the removal of the immunostimulatory CD137 ligand from HRS cells as well as from surrounding antigen presenting cells. This inhibits T-cell co-stimulation and supports the immune evasion of Hodgkin's lymphoma. © 2013 Landes Bioscience.

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Pang, W. L., Ho, W. T., & Schwarz, H. (2013). Ectopic CD137 expression facilitates the escape of hodgkin and reed-sternberg cells from immunosurveillance. OncoImmunology, 2(4). https://doi.org/10.4161/onci.23441

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