Study of the Toxicological Effects of Flower of Hibiscus sabdariffa Aqueous Extract on some Histological Parameters of the Kidneys in Albino Rat

Abstract

The present study aimed to know the effect of the cold aqueous extract of the flower of Hibiscus sabdariffa on some histopathological parameters of the kidney in white rats, as this plant is used in the treatment of many diseases, the study included twenty laboratory white rat whose ages ranged between (2-3) Months while their weight reached the limits of (200-250) g, The animals were divided into four main groups, with five animals for each group., The first group was considered a control group that was given water and lunch freely, while the other groups were considered experimental groups and a dose of cold aqueous extract of the flower Hibiscus sabdariffa and a dose of (250,500,750)mg/kg of body weight respectively and after the end of a period The 30-day experiment, the animals were anesthetized by the closed method using chloroform, after which the animals were dissected and liver samples were taken to prepare the permanent tissue sections, The results of examining the prepared histological sections showed that there were no histological changes in the liver tissues of the animals vaccinated with the extract with the three dose in a row where the cortex, pulp, glomerulus, and convoluted tubule near and distant were distinguished. Many health problems arising from exposure to toxins in the body that cause oxidative stress as a result of the release of free radicals in the blood.