A mechanical basis for chromosome function

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Abstract

We propose that chromosome function is governed by internal mechanical forces generated by programmed tendencies for expansion of the DNA/chromatin fiber against constraining features.

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Kleckner, N., Zickler, D., Jones, G. H., Dekker, J., Padmore, R., Henle, J., & Hutchinson, J. (2004). A mechanical basis for chromosome function. Proceedings of the National Academy of Sciences of the United States of America, 101(34), 12592–12597. https://doi.org/10.1073/pnas.0402724101

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