The RCAS vector system

Abstract

There are a large number of RCAS vectors (and ancillary tools, including the adaptors, mammalian cell lines expressing receptors like tva, and tva transgenic mice). This system can be used for a number of different purposes including studying viral replication, gene function, development, and cancer. The recent demonstration that the vector system can be used to express RNAi suggests novel uses for the vectors and the recognition that RCAS vectors can be used to infect nondividing cells also suggests new applications. It is likely that, as we come to better understand retroviruses and their hosts, new uses for these vectors will be discovered. I certainly hope that this will be true.