Drosophila homologues of adenomatous polyposis coli (APC) and the formin diaphanous collaborate by a conserved mechanism to stimulate actin filament assembly

Abstract

Background: Vertebrate APC collaborates with Dia through its Basic domain to assemble actin filaments. Results: Despite limited sequence homology between the vertebrate and Drosophila APC Basic domains, Drosophila APC1 collaborates with Dia to stimulate actin assembly in vitro. Conclusion: The mechanism of actin assembly is highly conserved over evolution. Significance: APC-Dia collaborations may be crucial in a wide range of animal cells. Copyright © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.