Journal ArticleOPEN ACCESS

Twist of fate for acute promyelocytic leukemia: Trib3–TwIst1 interaction promotes resistance

Clinical Cancer Research (2019) 25(20) 6018-6020
DOI: 10.1158/1078-0432.CCR-19-2140
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Abstract

While acute promyelocytic leukemia has a good prognosis with all-trans retinoic acid (ATRA) treatment, ATRA resistance is a major obstacle. It is now demonstrated that TRIBBLES 3 (TRIB3) stabilizes TWIST1, leading to ATRA resistance. Peptides that disrupt this interaction lead to the degradation of TWIST1 and overcome ATRA resistance.

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Peeke, S. Z., & Gritsman, K. (2019). Twist of fate for acute promyelocytic leukemia: Trib3–TwIst1 interaction promotes resistance. Clinical Cancer Research, 25(20), 6018–6020. https://doi.org/10.1158/1078-0432.CCR-19-2140

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