Three cases of intentional isoniazid overdose – a life-threatening condition

Abstract

Currently, isoniazid (INH) overdose seems to be a growing and life-threatening problem, partly due to the recent national roll-out of INH preventive therapy (IPT) for HIV-positive adults. We present three cases, two of which were fatal, seen at Frere and Cecilia Makiwane hospitals, East London, South Africa over the past 16 months.