Association between transforming growth factor 1 polymorphisms and atrial fibrillation in essential hypertensive subjects

Abstract

Background. The association of TGF 1 polymorphisms and atrial fibrillation (AF) in essential hypertensive (EH) subjects remains unknown. Methods EH subjects with AF (EH+AF+) and sinus rhythm (EH+AF-) were enrolled. The polymorphisms of +869 T C at codon 10 and + 915 G C at codon 25, were genotyped. The clinical characteristics including serum TGF 1 levels were detected. Results. The GG genotypes of TGF 1 +915 G C at codon 25 were more prevalent in subjects from EH+AF+ group than those from EH+AF- group (P = 0.009). The subjects with GG genotype from EH+AF+ group had the highest mean serum TGF 1 level, which was significantly higher than that of GG genotype subjects from EH+AF- group (3.18 0.24 ng/dl vs.2.29 0.14 ng/dl, P < 0.05). Multiple analyses revealed that the TGF 1 GG genotype of +915 G C at codon 25 presented a 3.09 times higher risk in developing AF in the multivariate model after adjusting for age and gender. Conclusion. The polymorphisms of TGF 1 +915 G C at codon 25 were associated with occurrence of AF and serum TGF 1 level in EH subjects. © 2010 Wang et al; licensee BioMed Central Ltd.