8-Nitronaphthofuran Fused Urea Derivatives as Potential Antimicrobial Agents: Synthesis, Characterization and Pharmacological Studies

Abstract

Urea and its derivatives are an important class of compounds with diverse chemical and biological properties that are widely used in the chemical, pharmaceutical, and agrochemical industries. The present work focuses on the synthesis of 8-nitronaphthofuran fused urea-derivatives (4 a–j) and exploring their potent antimicrobial and antioxidant activities. The chemical structures of the synthesized compounds were determined by different physicochemical techniques. The antimicrobial and antioxidant activities are carried out and tested compounds showed considerable activity compared to the standard drugs. To justify the bio-efficacy of the newly synthesized compounds; the bio-activity results are compared with the in silico molecular docking study against the target enzyme glucosamine-fructose-6-phosphate aminotransferase and demonstrated effective hydrogen bonding affinity.