Cellular stress response cross talk maintains protein and energy homeostasis

Abstract

Maintenance of cellular homeostasis depends upon several pathways that allow a cell to respond and adapt to both envi- ronmental stress and changes in metabolic status. New work in this issue of The EMBO Journal reveals a mechanism of cross talk between heat shock factor 1 (HSF1), the primary regulator of the proteotoxic stress response, and AMP-activated protein kinase (AMPK), the primary sensor in the metabolic stress response. See