Abstract
Escherichia coli strain VKPM B-10182, obtained by chemical mutagenesis from E. coli strain ATCC 9637, produces cephalosporin acid synthetase employed in the synthesis of β-lactam antibiotics, such as cefazolin. The draft genome sequence of strain VKPM B-10182 revealed 32 indels and 1,780 point mutations that might account for the improvement in antibiotic synthesis that we observed.
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CITATION STYLE
Mardanov, A. V., Eldarov, M. A., Sklyarenko, A. V., Dumina, M. V., Beletsky, A. V., Yarotsky, S. V., & Ravin, N. V. (2014). Draft genome sequence of Escherichia coli strain VKPM B-10182, producing the enzyme for synthesis of cephalosporin acids. Genome Announcements, 2(6). https://doi.org/10.1128/genomeA.01222-14
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