Silica Sulfuric acid as a efficient and recyclable solid acid catalyst for the one-pot synthesis of 2,4,6-triaylpyridines under solvent free conditions

Abstract

An efficient synthesis of 2,4,6-triarylpyridines is achieved via a three-component reaction of acetophenone, aryl aldehydes and ammonium acetate in one-pot under solvent-free conditions. The reaction work-up is very simple and the catalyst can be easily separated from the reaction mixture and reused three times in subsequent reactions.