067. INFLUENCE OF COMPONENTS OF METABOLIC SYNDROME ON THE COURSE OF PSORIATIC ARTHRITIS

Abstract

Background: This study defined the criteria of the metabolic syndrome (MS) and their connection with clinical course of psoriatic arthritis (PsA). Methods: The study involved 42 patients with PsA diagnosed based on the classification criteria of CASPAR. Average age of patients 36.52 ± 11.27 years, disease duration prior to enrollment 12.4 months (SD 9.2 months. 70.8% had PsA, 29.2% had interictal period. Statistical analysis of data is made using Student's t-test (level of reliability P<0.05). control group consisted of 14 healthy men. Results: Among the 72 patients with PsA, MS was revealed in 46 (63.9%). MS criteria were: abdominal obesity (waist circumference OT≥102cm to 69.7%), hypertension (SAP≥138, DAP≥85mmHg, 80.5%), hyperglycemia (HG≥6,1mmol/L in 20.8%), dyslipidemia: increased levels HS≥190mg/dl, and 26.4% TG≥150mg/dl, and also increase uric acid levels (MC) ≥360 umol/L, 63.9%, and the concentration a high-sensitivity (C-RP≥5mg/ml). In addition, 55.5% of hypertension were as follows concomitant diseases: coronary heart disease (CHD) (31.4%), diabetes mellitus type 2 (16.7%), chronic renal failure (12.5%), chronic heart failure (13.9%). Hypertension was associated with coronary artery disease in 34.7%, prior stroke in 11.2% myocardial infarction and 15.3%. It was found that obesity and hypertension was preceded by the development of PsA in 36 of 46 (78.3%) of patients with MS. Increasing the number of MS criteria contributed to the increase hyperuricemia and increase the number of afflicted joints was more severe course related diseases and their complications. Increasing of the concentration of CRP (15.2 ± 3.6mg/ml versus 3.8 ± 0.6 mg/ml) were observed in patients with PsA with MS more frequent and prolonged exacerbations of PsA per year (4.2 ± 1.1), those without metabolic syndrome [2.1 (SD 0.8)] (P<0.05). Conclusion: Psoriatic arthritis is often associated with metabolic syndrome, which complicates the clinical course of disease. Number of criteria of metabolic syndrome affects the severity of concomitant cardiovascular and renal disease. Increasing the concentration of CRP predicts frequent exacerbations of PsA.