Genomic confirmation of vancomycinresistant Enterococcus transmission from deceased donor to liver transplant recipient

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Abstract

In a liver transplant recipient with vancomycin-resistant Enterococcus (VRE) surgical site and bloodstream infection, a combination of pulsed-field gel electrophoresis, multilocus sequence typing, and whole genome sequencing identified that donor and recipient VRE isolates were highly similar when compared to time-matched hospital isolates. Comparison of de novo assembled isolate genomes was highly suggestive of transplant transmission rather than hospital-acquired transmission and also identified subtle internal rearrangements between donor and recipient missed by other genomic approaches. Given the improved resolution, whole-genome assembly of pathogen genomes is likely to become an essential tool for investigation of potential organ transplant transmissions.

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APA

Bashir, A., Attie, O., Sullivan, M., Sebra, R., Singh, K. V., Altman, D., … Huprikar, S. (2017). Genomic confirmation of vancomycinresistant Enterococcus transmission from deceased donor to liver transplant recipient. PLoS ONE, 12(3). https://doi.org/10.1371/journal.pone.0170449

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