Association of glutathione S -transferase M1 and T1 genotypes with asthma: A meta-analysis

Abstract

Background: We performed an updated meta-analysis to clarify the relationship between glutathione S-transferase Mu and theta (GSTM1 and GSTT1, respectively) null/positive genotypes and asthma. Methods: We performed a literature search using PubMed and Web of Science databases in August 2019. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to assess the role of GSTM1 and GSTT1 genotypes in the risk of asthma. Results: Overall, we found a significant association with asthma risk in the general population for both the GSTM1 genotype (OR=1.21; 95% CI: 1.07-1.35; P <500, but not a sample size >2000. Conclusion: Our meta-analysis provides evidence that GSTM1 and GSTT1 genotypes could be used as asthma-associated biomarkers.