Noninvasive blood glucose measurement by ultrasound-modulated optical technique

Abstract

We present a method for the noninvasive measurement of blood glucose levels, which are determined by the ultrasound-modulated optical technique. The method is based on the optical scattering coefficient. A sensitivity analysis of the ultrasound-modulated light signals in a scattering medium is conducted. Glucose concentrations in intralipid and hemoglobin solutions are measured using the modulation depth of ultrasound-modulated scattered light. The effects of incident light intensity and sample temperature on the ultrasound-modulated signals are also estimated. Preliminary experimental results suggest that the proposed method is a promising technique for noninvasive blood glucose measurement. © 2013 Chinese Optics Letters.