Force spectroscopy on a single polymer chain

Abstract

A novel technique to extend the capability of atomic force microscopy (AFM) to force spectroscopy of a single polymer chain (nanofishing) is given together with its problems and perspective. Special emphasis is placed on the definition of the origin of extension length and the invalidity of existing theoretical models for quasi-static nanofishing. Dynamic nanofishing in cooperation with forced oscillation or with noise analysis is also given to discuss the viscoelastic nature of a single polymer chain. Fast nanofishing will reveal the intramolecular entanglement and its relaxation properties.