A new ascochlorin derivative from Cylindrocarpon sp. FKI-4602

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Abstract

Cylindrol A 5, a new ascochlorin congener, was isolated along with 14 known compounds from the culture broth of Cylindrocarpon sp. FKI-4602 by solvent extraction, octadecylsilane column chromatography and HPLC. The structure of cylindrol A 5 was elucidated by spectral analyses, including NMR. The compound has an ascochlorin skeleton consisting of a resorcin aldehyde and a cyclohexanone moieties. Cylindrol A 5 showed moderate antimicrobial activity against Bacillus subtilis, Kocuria rhizophila, Mycobacterium smegmatis and Acholeplasma laidlawii. The biosynthetic pathway to cylindrol A 5 was deduced from the 14 isolated metabolites of the fungal strain. © 2013 Japan Antibiotics Research Association All rights reserved.

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Kawaguchi, M., Fukuda, T., Uchida, R., Nonaka, K., Masuma, R., & Tomoda, H. (2013). A new ascochlorin derivative from Cylindrocarpon sp. FKI-4602. Journal of Antibiotics, 66(1), 23–29. https://doi.org/10.1038/ja.2012.75

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