Chemical composition of rhizome oleoresin and anti-inflammatory, antinociceptive and antipyretic activity of oleoresins of Alpinia Allughas Roscoe. From Tarai Region Of Uttarakhand

Abstract

The investigation of volatile constituents of the rhizome oleoresin of Alpinia allughas Roscoe. growing in tarai region of Kumaun hills, Uttarakhand, revealed the presence of 55 terpenoids. The major constituents identified in the rhizome oleoresin were α-eudesmol (21.3%), β-selinene (13.9%), valencene (9.6%), borneol (7.1%), α-humulene (5.3%)and7-epi-α-selinene (5.2%). Other minor constituents identified were (E)-β-caryophyllene (3.8%), (6 E)-nerolidol (3.5%), (E,E)-farnesol (3.2%), caryophyllene oxide (2.5%), humulene oxide (2.7%), bornyl acetate (1.9%), coranarin- E (1.8%), linalool (1.8%) and α-terpineol (1.6%). The total identified constituents contribute 97.0% of the oleoresin. The rhizomes oleoresins exhibited significant antinociceptive activity with 34.79% inhibition at 50 mg/kg BW and 43.24% at 100mg/kg BW compared to standard drug ibuprofen (40mg/kg BW), it also showed antipyretic activity in dose dependent manner with temperature reduction 77.57±5.88% at 50mg/kg BW and 98.95±3.95% at 100mg/kg BW after 3h. Oleoresin also showed 29.23% inhibition of carrageenan-induced paw edema at 50mg/kg BW. and 39.92% inhibition at 100mg/kg BW in comparison to ibuprofen 40.06% at 40mg/kg BW.