Different chromosomal translocations in MALT lymphoma promote cancer through a common mechanism

Abstract

Extranodal marginal zone B-cell lymphoma of mucosal-associated lymphoid tissue (MALT lymphoma) comprises 7%-8% of all B-cell lymphomas. In many cases of MALT lymphoma, there is a history of chronic inflammation or autoimmune disorder. Mucosal-associated lymphoid tissue lymphoma has been associated with several chromosomal alterations; remarkably, the 3 most common of these translocations target a specific portion of the nuclear factor kappaB (NF-κB) transcription regulator pathway. This transcription control mechanism is intimately linked to the means by which lymphocytes are activated and maintained by a chronic inflammatory stimulus. Recent discoveries suggest this pathway is an attractive therapeutic target for lymphoid malignancies.