Association of serum soluble endoglin with preeclampsia

Abstract

Objectives: To determine and compare the serum soluble Endoglin (sEng) levels among pregnant women with preeclampsia (PE) and women having normal pregnancy. Methodology: This cross-sectional study was carried at IBMS KMU and the data collection was carried out in the department of Gynecology & obstetrics, Lady Reading hospital, Peshawar, from June 2019 to July 2020. A total of 138 pregnant women at the gestational age of 26-30 weeks were included. The study sample was divided into two groups. Group A: Pre-Eclamptic (n=92). Group B: Normotensive Control Group; women with normal pregnancy (n=46). Results: Mean age in PE group was considerably lower as compared to control group (p<0.001). Similarly, mean age at the time of marriage was significantly lower in the PE group compared to control group (19.40±1.92 vs 21.17±2.19 years, p<0.001). Both mean systolic and diastolic blood pressure in PE and control group was noted to be significantly differed (169.78 ± 16.64/ 114.62 ± 9.34 vs 119.57 ± 1.07/ 78.48 ± 5.56 mm Hg, p<0.05). PE group had statistically significantly higher sEng levels compared to control group (13.42 ± 2.94vs3.47 ± 2.80 ng /ml, p <0.001).