Synthesis of novel N 1 and N 2 indazole derivatives

Abstract

The alkylation of 5-cyano indazoles 2 in the presence of readily available imidizolium salts (ionic liquids) (Bmim)BF 4 as phase transfer catalyst were performed to afford the regio isomers N 1-and N 2-(substituted alkyl)-5-cyano indazoles. The N 1-alkylated cyano indazoles were converted to the corresponding N 1-(substituted alkyl)-5-aminomethyl and 5-carbaldehydes 5(a-f) and 6(a-f). © 2012 Hindawi Publishing Corporation.