45,X/46,X dic (Y) mosaicism in a phenotypic male

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Abstract

Cytogenetic analysis, confirmed by in situ hybridisation studies, showed a mosaic 45,X/46,X dic (Y) (q12) karyotype in a 14 year old boy who was initially diagnosed as having Noonan's syndrome. He made an early response to recombinant growth hormone; this suggests that this treatment may improve final height.

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Batstone, P. J., Faed, M. J. W., Jung, R. T., & Gosden, J. (1991). 45,X/46,X dic (Y) mosaicism in a phenotypic male. Archives of Disease in Childhood, 66(2), 252–253. https://doi.org/10.1136/adc.66.2.252

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