Synthesis and Characterization of Dextran coated Iron Oxide Nanoparticles as a T1 Contrast Agent

Abstract

This is a second part of iron oxide nanoparticles synthesis by co-precipitation method with various PH values. This study includes stabilizing iron oxide nanoparticles with dextran of molecular weight 10000 Da by aqueous route, then study its characteristics with AFM, FTIR and VSM also using the stabilized material as a contrast agent in T1-weighted image then compare the contrast enhancement with gadolinium based commercially available contrast agent (MagnevistTM). Ph values were (7,11,14), all samples were injected to mice bodies then imaged with MRI best result of T1 contrast enhancement was obtained from sample with Ph 14 compared with gadolinium-based T1 contrast agent with no toxic effects.