ROS-inducible DNA cross-linking agent as a new anticancer prodrug building block

Abstract

Down at the crossed code: Novel arylboronic ester and biarylboronic ester derivatives were synthesized. Compound 1 can be activated by hydrogen peroxide to release 2,5-bis(trimethylammonium) benzyl-1,4-diol (2), which leads to interstrand cross-link formation and DNA alkylation (see scheme). Compound 1 provides a novel building block for the development of H 2O 2-targeting anticancer prodrugs. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.