Desmosines in human urine. Amounts in early development and in Marfan's syndrome

Abstract

Desmosines from 24h human urine samples were isolated, characterized and quantified. The desmosines are in peptidyl form (1000-1500 molecular weight), and their amount is decreased by two-thirds between 7 and 25 years of age. Patients with Marfan's syndrome have significantly lower urinary amounts of desmosines than do comparable controls during the early developmental period.