Dislocation by the m-AAA protease increases the threshold hydrophobicity for retention of transmembrane helices in the inner membrane of yeast mitochondria

Abstract

Background: The m-AAA protease dislocates transmembrane segments from the mitochondrial inner membrane. Results: The presence of the m-AAA protease increases the hydrophobicity required for a transmembrane segment to remain in the membrane. Conclusion: The hydrophobicity thresholds for transmembrane segment retention in the mitochondrial inner membrane differ with or without the m-AAA protease. Significance: Retention of a transmembrane domain in the inner membrane depends on recognition by the m-AAA protease.© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.