Anti-Ro and anti-La autoantibodies induce TNF-α production by human salivary gland cells: An in vitro study

Abstract

In this report, we demonstrate that both TNFR1 and the TNFR2 are expressed on the salivary gland cell line A-253 cell membrane. Furthermore, cell treatment with anti-Ro and anti-La autoantibodies from Sjögren IgG determined TNF-α production, clarifying which could be the inducer of the extrinsic pathway of apoptosis in salivary gland cells.