Identification of the ISWI chromatin remodeling complex of the early branching eukaryote trypanosoma brucei

Abstract

Background: Eukaryotes typically encode a range of ISWI chromatin remodeling complexes with different functions. Results: We have identified and analyzed three novel ISWI partners in the early branching eukaryote Trypanosoma brucei. Conclusion: T. brucei appears to have a single major ISWI complex. Significance: This unusually simple ISWI configuration could be a consequence of the relative lack of transcriptional regulation in this ancient eukaryote.