Peripheral immune cell gene expression predicts survival of patients with non-small cell lung cancer

22Citations
Citations of this article
40Readers
Mendeley users who have this article in their library.

Abstract

Prediction of cancer recurrence in patients with non-small cell lung cancer (NSCLC) currently relies on the assessment of clinical characteristics including age, tumor stage, and smoking history. A better prediction of early stage cancer patients with poorer survival and late stage patients with better survival is needed to design patient-tailored treatment protocols. We analyzed gene expression in RNA from peripheral blood mononuclear cells (PBMC) of NSCLC patients to identify signatures predictive of overall patient survival. We find that PBMC gene expression patterns from NSCLC patients, like patterns from tumors, have information predictive of patient outcomes. We identify and validate a 26 gene prognostic panel that is independent of clinical stage. Many additional prognostic genes are specific to myeloid cells and are more highly expressed in patients with shorter survival. We also observe that significant numbers of prognostic genes change expression levels in PBMC collected after tumor resection. These post-surgery gene expression profiles may provide a means to re-evaluate prognosis over time. These studies further suggest that patient outcomes are not solely determined by tumor gene expression profiles but can also be influenced by the immune response as reflected in peripheral immune cells. © 2012 Kossenkov et al.

Cite

CITATION STYLE

APA

Kossenkov, A. V., Dawany, N., Evans, T. L., Kucharczuk, J. C., Albelda, S. M., Showe, L. C., … Vachani, A. (2012). Peripheral immune cell gene expression predicts survival of patients with non-small cell lung cancer. PLoS ONE, 7(3). https://doi.org/10.1371/journal.pone.0034392

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free