From phase diagram to the design of strontium-containing carrier

Abstract

Strontium (Sr) ions are known for its role on increasing bone mineral density. However, a high dosage through mouth may cause many side effects. An alternative to provide a low but steady release at the location of bone defect is therefore explored. In the present study, various amounts of strontium sulfate (SrSO4) were dissolved into calcium sulfate (CaSO4) at elevated temperatures. The release of Sr ions from the (Ca,Sr)SO4 solid solution into various aqueous solutions was then measured. Through the control of Sr content in (Ca,Sr)SO4, the Sr amount releasing into the aqueous solutions could be tailored. After implanting a solid solution into distal femur in rat, a low release of Sr into blood was confirmed.