Impedance spectroscopy of ion channels in tethered lipid bilayers

Abstract

The efficient analysis of the function of ion channels is an important task in many different fields ranging from (bio)analytics and drug-screening to nanoelectronics. Here, the modulation of the channel activity of a synthetic ligand gated ion channel by a specific antibody is measured in tethered lipid bilayers by impedance spectroscopy. Tethered single lipid bilayers with exceptionally high electrical resistances suitable for the detection of a few channels are presented. © 2005 The Surface Science Society of Japan.