Effect lutein of marigold flower (Tagetes erecta L.) on decreasing glucose and malondialdehyde levels in Alloxan-induced blood mice

Abstract

Marigold (Tagetes erecta L.) is an ornamental plant of the Asteraceae family. The flowers are used to cure various diseases, including antioxidants and antidiabetic. Lutein had been identified as the main pigment component in marigold flowers. Lutein is more effective than carotene in inhibiting the auto-oxidation of cellular lipids protecting against oxidant-induced cell damage. Antioxidants are important in preventing diabetes, with low levels of plasma antioxidants implicated as a risk factor for the development of the disease. Humans are not able to synthesise lutein, so they can acquire it solely by the consumption of fruits, vegetables, and food supplements. This research was to find out the potential of lutein of Marigold flower as an antidiabetic and natural antioxidant. In this study, white Sparague Dawley rats employed, and it has been treated for diabetic-induced by Alloxan. Seven groups were performed in this experiment, i.e. The normal control (Group I), The negative control was given CMC-Na 0.5% (Group II), The positive control of diabetic were given Glibenclamide 5mg/kg bw (Group III), The positive control of antioxidant were given vitamin E 10mg/kg bw (Group IV), The experiment were given lutein extract in doses 40, 80 and 160 mg/kg bw respectively (Group V, VI, VII). The result showed that the Lutein extract from marigold flowers has the potential to reduce blood glucose levels and as an antioxidant characterized by a decrease in the levels of malondialdehyde in mice.