A novel platelet concentrate for guided bone regeneration: Titanium prepared platelet-rich fibrin (T-PRF)

Abstract

In our previous studies, we developed a novel platelet-rich product that we called titaniumprepared platelet-rich fibrin (T-PRF). T-PRF is based on the hypothesis that titanium may be more effective at activating platelets than the silica activators used with glass tubes in Chouckroun's platelet-rich fibrin (PRF). This study aimed to assess the effects of T-PRF on bone augmentation in a rabbit calvaria model. Twenty-four adult male New Zealand rabbits were used in the study. T-PRF alone, inorganic bovine bone (ABB), and T-PRF + ABB were used in the experimental groups. No material was used in the control group. Half of the animals were sacrificed after one month, and the remaining animals were sacrificed 3 months later. A histomorphometric evaluation was performed to compare new bone formation among the groups. More new bone areas were determined in the T-PRF group than the other three groups. While less new bone formation was observed than in the T-PRF group, more new bone formation occurred in the ABB and T-PRF + ABB groups when compared to the control group. Basing on the results of this study, we can say that T-PRF membrane can be successfully used for bone augmentation.