Association between left ventricle diastolic dysfunction and circadian blood pressure pattern in arterial hypertension

Abstract

Objective: To assess the relationship between left ventricular diastolic dysfunction (LVDD) and circadian blood pressure (BP) pattern in arterial hypertension (AH). Methods: A total of 96 patients with AH of I-II grades were examined. Transthoracic echocardiography was performed using a high-end ultrasound device GE Vivid 7 Pro (USA). 24-hour Ambulatory BP Monitoring was carried out using a Microlife Watch BP 03 device on the non-dominant arm. Statistical analysis of the obtained results was carried out using the Statistica 10.0 application package. Results: After echocardiography all patients were divided into two groups. The first group is patients with AH and LVDD (n = 37), second group is patients with AH without LVDD (n = 59). The dipper pattern of systolic BP (SBP) was significantly more common in patients in the second group (p = 0.014). The non-dipper pattern of diastolic BP (DBP) was significantly more common in patients of group 1 (p = 0.047). The odds ratio of LVDD developing in patients with AH and a non-dipper pattern of SBP and DBP was 2.907 (95% confidence interval (CI) 1.233–6.852) and 3.329 (95% CI 1.346–8.234), respectively. Conclusion: A non-dipper pattern of SBP and DBP was significantly associated with LVDD and may be a therapeutic target for preservation of the diastolic function.