Risk factor profile of chronic non-communicable diseases in different obesity phenotypes

Abstract

Aim. To study the features of modifiable biological and behavioral risk factors of chronic noncommunicable diseases in individuals with different metabolic phenotypes. Material and methods. The observation group consisted of 97 patients who underwent the first stage of physical examination (age, Me 57,0 [42,0-66,0] years with a predominance of women - 80,4%). The examined patients were divided into 4 groups with metabolically healthy and unhealthy phenotypes depending on body mass index and presence of abdominal obesity. Biological and behavioral risk factors for chronic noncommunicable diseases were assessed in all patients based on the data obtained during the physical examination. Statistical processing was performed using IBM SPSS Statistics 20. Results and discussion. Unhealthy diet (78,4%), hypercholesterolemia (71,1%), abdominal obesity (64,9%) were the most frequent risk factors in the whole group of patients. Against the background of no significant differences in the frequency of behavioral risk factors of CNCD in thepatients of the compared groups, significant differences in the features of biological risk factors were revealed. Individuals with the metabolically unhealthy phenotype had arterial hypertension, hypercholesterolemia, fasting hyperglycemia, and diabetes mellitus more frequently. Those patients showed higher values of blood pressure, total cholesterol, and fasting glycemia. Conclusion. More than half of the total cohort had abdominal obesity, hypercholesterolemia, and an unhealthy diet. The presence of abdominal obesity was associated with a higher frequency and severity of biological risk factors for chronic noncommunicable diseases such as arterial hypertension, hypercholesterolemia, and hyperglycemia.