Validity of EQ-5D utility index and minimal clinically important difference estimation among patients with chronic obstructive pulmonary disease

30Citations
Citations of this article
65Readers
Mendeley users who have this article in their library.

Abstract

Background: The discriminatory ability of multi-attribute utility (MAU) measures compared to condition-specific measures (CSM) in assessing health-related quality of life (HRQoL) among patients with chronic obstructive pulmonary disease (COPD) is an unsettled issue. This study investigated the quality of life of patients with COPD with three different HRQoL instruments and examined whether they could differentiate between adjacent severity groups in a statistically and clinically meaningful manner. In the process, the minimal clinically important differences (MCID) of the EQ-5D utility index were estimated. Methods: Cross-sectional survey data were collected from patients with mild to very severe COPD in South Korea. In addition to demographic and clinical information, the following HRQoL questionnaires were used: The three-level five-dimensional Euro-Quality of Life tool (EQ-5D-3L), the EQ-Visual Analog Scale (EQ-VAS), and the Chronic Obstructive Pulmonary Disease Assessment Test (CAT). Patients' health-related quality of life was analyzed with reference to severity groups based on the Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification. To investigate the discriminatory ability of the HRQoL instruments between COPD severity groups, tests examining variance, covariance, and standardized mean difference were performed. After estimating the MCID of the EQ-5D utility index using the anchor-based method, we investigated whether the differences in the EQ-5D utility scores between groups exceeded the clinically meaningful minimum level. Results: A total of 298 patients completed this study. All the quality of life scores showed statistically significant differences between the GOLD severity groups. The pooled MCID estimate for the EQ-5D utility index was 0.028 (range: 0.017-0.033). Even after adjusting for other factors affecting quality of life, the EQ-5D utility index differentiated the GOLD groups well. Conclusions: We conclude that the EQ-5D utility index is a valid instrument for measuring the quality of life of patients with COPD, and the pooled MCID estimate for the EQ-5D utility index was 0.028.

References Powered by Scopus

Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) workshop summary

4497Citations
N/AReaders
Get full text

EQ-5D: A measure of health status from the EuroQol Group

4337Citations
N/AReaders
Get full text

Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease GOLD executive summary

4200Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Discriminative Accuracy of Chronic Obstructive Pulmonary Disease Screening Instruments in 3 Low- and Middle-Income Country Settings

44Citations
N/AReaders
Get full text

Patient-reported outcomes and patient-reported outcome measures in interstitial lung disease: Where to go from here?

26Citations
N/AReaders
Get full text

Health-related quality of life and related factors in persons with preserved ratio impaired spirometry: Data from the korea national health and nutrition examination surve

17Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Bae, E., Choi, S. E., Lee, H., Shin, G., & Kang, D. (2020). Validity of EQ-5D utility index and minimal clinically important difference estimation among patients with chronic obstructive pulmonary disease. BMC Pulmonary Medicine, 20(1). https://doi.org/10.1186/s12890-020-1116-z

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 16

57%

Researcher 6

21%

Professor / Associate Prof. 3

11%

Lecturer / Post doc 3

11%

Readers' Discipline

Tooltip

Medicine and Dentistry 12

50%

Nursing and Health Professions 9

38%

Veterinary Science and Veterinary Medic... 2

8%

Sports and Recreations 1

4%

Save time finding and organizing research with Mendeley

Sign up for free