The Association Between Common Clinical Characteristics and Postoperative Morbidity and Overall Survival in Patients with Glioblastoma

Abstract

© AlphaMed Press 2018 Background: The impact of noncancerous factors on the morbidity and mortality of glioblastoma multiforme (GBM) has not been well studied. Using a large surgical cohort, we examined the association between multiple clinical characteristics and postoperative morbidities and survival in patients with GBM. Materials and Methods: The study included 404 consecutive GBM patients who underwent initial tumor resection at MD Anderson Cancer Center between January 1, 2010, and December 31, 2014. Data about clinical characteristics, treatments, and postoperative complications were collected. The associations between clinical parameters and postoperative complications and survival were analyzed. Results: Charlson Comorbidity Index was positively related to a higher incidence of postoperative total (odds ratio [OR] = 1.20; p =.002) and neurological (OR = 1.18; p =.011) complications. Preoperative systolic blood pressure (SBp) over 140 mmHg was associated with a higher incidence of postoperative intracranial hemorrhage (OR = 4.42; p =.039) and longer hospital stay (OR = 2.48; p =.015). Greater postoperative fluctuation of SBp (OR = 1.14; p =.025) and blood glucose (mmol/L; OR = 1.48; p =.023) were related to a higher incidence of neurological complications, whereas higher postoperative blood glucose (OR = 0.64; p <124 mmHg; hazard ratio [HR] = 1.47; p =.010) and higher blood glucose (HR = 1.12; p