Structures of a Novel 2-Arylbenzofuran Derivative and Two Flavone Derivatives from the Cultivated Mulberry Tree (Morus lhou KOIDZ.)

Abstract

A new 2-arylbenzofuran derivative, mulberrofuran H and two isoprenylated flavones, kuwanons S and T, were isolated from the ethyl acetate extract of the root bark of cultivated mulberry tree (Japanese name “Roso,” a cultivated variety of Morus lhou Koidz.). The structures of mulberrofuran H and kuwanons S and T were shown to be 1, 2, and 3, respectively, on the basis of spectral evidence. Mulberrofuran H can be regarded biogenetically as a variation of a Diels-Alder type adduct of a chalcone derivative and a dehydroprenyl-2-arylbenzofuran derivative. © 1985, The Pharmaceutical Society of Japan. All rights reserved.