Role of phosphopantetheinyl transferase genes in antibiotic production by Streptomyces coelicolor

Abstract

The phosphopantetheinyl transferase genes SCO5883 (redU) and SCO6673 were disrupted in Streptomyces coelicolor. The redU mutants did not synthesize undecylprodigiosin, while SCO6673 mutants failed to produce calcium-dependent antibiotic. Neither gene was essential for actinorhodin production or morphological development in S. coelicolor, although their mutation could influence these processes. Copyright © 2008, American Society for Microbiology. All Rights Reserved.