Role of AMPK and its possible interactions in metformin therapy and physical exercise-Research perspectives

Abstract

Insulin resistance results in increased blood glucose, called hyperglycemia, leading to the onset of diabetes mellitus. A better function in glucose uptake caused by metformin and physical exercise are interesting strategies for the control of hyperglycemia. Studies demonstrate expressive and beneficial results of physical exercise associated with metformin in response to the activation of a protein called AMPK, which stimulates Glut4 translocation, which improves the glucose sensitivity and hyperglycemia reduction. The present review seeks understanding on the effects of physical exercise and Metformin on the AMPK enzyme in the metabolism of glucose in diabetic people.