Removal of Endotoxins and Cytokines by Plasmapheresis Filtration with Plasma Exchange Therapy (TPE) Could Benefit Patients with Covid-19 in Critical Condition

Abstract

Background: The COVID-19 pandemic originated in Wuhan, China is rapidly and continuously spreading globally and can result in significant severe respiratory morbidity and mortality. The severe damage of the lung tissue can result in acute respiratory distress syndrome (ARDS), which can further precipitate septic shock. These two complications are the major contributors to the intensive care unit (ICU) care and mortality from COVID-19 in patients older than 60 years, with smoking history, and comorbid medical conditions. The possible high mortality rate of COVID-19 can be connected to the increasing of Th17 cells activity mainly stimulated by IL-6 and IL-23.