Asymmetric synthesis of trifluoromethylated amines via catalytic enantioselective isomerization of imines

Abstract

A new approach toward the asymmetric synthesis of optically active trifluoromethylated amines was enabled by an unprecedented, highly enantioselective catalytic isomerization of trifluoromethyl imines with a new chiral organic catalyst. Not only aryl but also alkyl trifluoromethylated amines could be obtained in high enantioselectivities. © 2012 American Chemical Society.