Blocking Kv1.3 channels inhibits Th2 lymphocyte function and treats a rat model of asthma

Abstract

Background: CCR7+ effector memory T lymphocytes are major players in lung inflammation that characterizes allergic asthma. Results: Blocking KV1.3 channels reduced the severity of an ovalbumin-induced model of asthma in rats. Conclusion: KV1.3 channels are attractive targets for immunomodulation and the treatment of allergic asthma. Significance: Selective KV1.3 channel blockers may prove beneficial in the treatment of asthma. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.