Effectiveness of azithromycin in aspiration pneumonia: A prospective observational study

Abstract

Background: Aspiration pneumonia is an urgent health concern with high mortality and long hospitalization in industrialized and aging countries. However, there is no information about the effectiveness of azithromycin (AZM) for the treatment of aspiration pneumonia. This study investigated if AZM is effective for the treatment of aspiration pneumonia. Methods: Patients with aspiration pneumonia with no risk of multidrug-resistant pathogens were included in this prospective study at Kishiwada City Hospital from December 2011 to June 2013. Patients were divided into the ampicillin/sulbactam (ABPC/SBT) and AZM (intravenous injection) groups. The success rates of 1st-line antibiotic therapy, mortality, length of hospital stay, and total antibiotic costs were compared. Results: There were 81 and 36 patients in the ABPC/SBT and AZM groups, respectively. There was no significant difference in the success rate of 1st-line antibiotics between the groups (74.1% vs. 75.0%, respectively, = 1.000). Mortality and hospitalization periods did not differ between the 2 groups (11.1% vs. 8.3%, =0.753, and 22.3 ± 7.3 days vs. 20.5 ±8.1 days, =0.654, respectively). However, the total antibiotic costs were significantly lower in the AZM group than the ABPC/SBT group (2.19 ± 1.65 × 10,000 yen vs. 2.94 ± 1.67 × 10,000 yen, respectively, = 0.034). The febrile period of the ABPC/SBT group was significantly shorter than that of the AZM group (P= 0.025). Conclusions: In this small prospective non-randomized observational study, we found no statistically significant differences in mortality or antibiotic failure in patients receiving AZM compared to ABPC/SBT for the treatment of patients with aspiration pneumonia who require hospital admission and have no risk of drug-resistant pathogens. Therefore, AZM may be another first choice of antibiotic treatment for patients with aspiration pneumonia when they have no risk of multidrug-resistant pathogens.