DNA-catalyzed glycosylation using aryl glycoside donors

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Abstract

We report the identification by in vitro selection of Zn2+/Mn2+-dependent deoxyribozymes that glycosylate the 3′-OH of a DNA oligonucleotide. Both β and α anomers of aryl glycosides can be used as the glycosyl donors. Individual deoxyribozymes are each specific for a particular donor anomer.

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Hesser, A. R., Brandsen, B. M., Walsh, S. M., Wang, P., & Silverman, S. K. (2016). DNA-catalyzed glycosylation using aryl glycoside donors. Chemical Communications, 52(59), 9259–9262. https://doi.org/10.1039/c6cc04329a

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