The Role of the CPT Family in Cancer: Searching for New Therapeutic Strategies

Abstract

Numerous studies have demonstrated the key rate-limiting enzymes of the FAO (fatty acid oxidation) pathway, represented by the CPT family, play important roles in tumor proliferation, migration, invasion, stemness, apoptosis, chemoresistance, and metabolic stress. However, the current research on the CPT family focuses more on CPT1A and CPT1B, while relatively few studies have been conducted on CPT1C and CPT2 in tumors. Therefore, we look at molecular structural properties of the CPT family, the roles they play in tumorigenesis and development, the target drugs, and the possible regulatory roles of CPTs in energy metabolism reprogramming to help understand the current state of CPT family research and to search for new therapeutic strategies.