New diketopiperazines from the entomopathogenic fungus Verticillium hemipterigenum BCC 1449

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Abstract

Two new diketopiperazines, bisdethiodi(methylthio)-1-demethylhyalodendrin and 1-demethylhyalodendrin tetrasulfide, together with two known cyclodepsipeptides, enniatins B and B4, and two known pyrones, pyrenocines A and B, were isolated from a culture broth of the entomopathogenic fungus Verticillium hemipterigenum BCC 1449. These structures were elucidated using spectroscopic methods and X-ray crystallography. Antimalarial and cytotoxic activities of these compounds were evaluated.

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Nilanonta, C., Isaka, M., Kittakoop, P., Saenboonrueng, J., Rukachaisirikul, V., Kongsaeree, P., & Thebtaranonth, Y. (2003). New diketopiperazines from the entomopathogenic fungus Verticillium hemipterigenum BCC 1449. Journal of Antibiotics, 56(7), 647–651. https://doi.org/10.7164/antibiotics.56.647

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