Preparation of sulfated aminodeoxycelluloses

Abstract

Aminodeoxycelluloses and 6-amino-6-deoxystarch were sulfated with N,N-dimethylformamide-sulfur trioxide complex in order to obtain heparin-like anticoagulant molecules. Sulfated products obtained had a degree of substitution (DS) by the sulfate group, ca. 1.0. I.r spectra showed that the chemical structures of sodium 6-amino-6-deoxycellulose sulfate, sodium 2-amino-2-deoxycellulose sulfate, and sodium 6-amino-6-deoxystarch sulfate were similar to that of sodium heparinate. © 1980, The Society of Fiber Science and Technology, Japan. All rights reserved.