Gp1ba-Cre or Pf4-Cre: Pick your poison

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Abstract

In this issue of Blood, Nagy et al developed a novel Gp1ba-Cre mouse that uses the endogenous Gp1ba locus that encodes the glycoprotein Iba (GPIba) subunit of the GPib-IX receptor to drive Cre expression in murine megakaryocytes (MKs) for targeted ablation of floxed genes.

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Gollomp, K., & Poncz, M. (2019). Gp1ba-Cre or Pf4-Cre: Pick your poison. Blood, 133(4), 287–288. https://doi.org/10.1182/blood-2018-11-887513

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